changes in leukocyte subpopulations with decline in glomerular filtration rate in patients with type 2 diabetes
نویسندگان
چکیده
recent studies suggested the role of white blood cells (wbcs) in the pathogenesis and complications of type 2 diabetes. increased wbc counts predict mortality in patients with chronic kidney disease (ckd). in this study alterations in wbc subpopulations in diabetic patients with non-dialysis dependent ckd are investigated. this was a cross-sectional study on 376 participants, including 272 diabetic patients and 104 healthy controls. total and differential wbc counts were compared among diabetics with ckd, diabetics without ckd and controls. among patients with type 2 diabetes, there was no significant difference in total wbc count between those with and without ckd. diabetic patients with ckd had higher neutrophil, monocyte and eosinophil and lower lymphocyte count compared with both diabetic patients without ckd and healthy controls. except for monocytes, a significant association was observed between gfr and differential wbc counts, which persisted after adjustment for conventional diabetes riskfactors (r2=0.272, p < 0.001 for regression model). neutrophil/lymphocyte ratio was the best predictor ofgfr in total study population (beta= -1.995 ± 0.45, p
منابع مشابه
Changes in leukocyte subpopulations with decline in glomerular filtration rate in patients with type 2 diabetes.
Recent studies suggested the role of white blood cells (WBCs) in the pathogenesis and complications of type 2 diabetes. Increased WBC counts predict mortality in patients with chronic kidney disease (CKD). In this study alterations in WBC subpopulations in diabetic patients with non-dialysis dependent CKD are investigated. This was a cross-sectional study on 376 participants, including 272 d...
متن کاملThe Association of Glomerular Filtration Rate with Coronary Artery Disease in Type 2 Diabetic Patients
Objective: Chronic kidney disease (CKD) and diabetes mellitus can influence coronary artery disease (CAD) independently. The aim of this study was to evaluate the association of glomerular filtration rate (GFR) and CAD in type 2 diabetic patients (T2DM). Materials and Methods: This cross sectional study evaluated 3624 T2DM patients with clinical presentation of CAD whose documents were registe...
متن کاملRisks for glomerular filtration rate decline in association with progression of albuminuria in type 2 diabetes.
BACKGROUND The aim of this study was to investigate the annual rate of glomerular filtration rate (GFR) decline and risks for this decline in association with albuminuria progression in type 2 diabetes. METHODS An observational 4-year cohort study was performed on 1002 subjects with preserved GFR (699 normoalbuminuric), and the predictive value of baseline variables on the GFR slope was inves...
متن کاملGlomerular Filtration Rate Changes in Neonates with Sepsis Treated with Amikacin and Cefotaxime
Background and purpose: Aminoglycosides (AG) such as Amikacin that are widely used to prevent and treat infections in neonates have nephrotoxic effects. The aim of this study was to evaluate the role of urinary index to Glomerular filtration rate (GFR) in diagnosis of tubular renal injury following administration of Amikacin in neonates admitted to neonatal intensive care unit (NICU). Materia...
متن کاملassociation of microalbuminuria and estimated glomerular filtration rate with carotid intima-media thickness in patients with type 2 diabetes mellitus
conclusions our study shows a relationship between cimt and renal parameters, including egfr and albuminuria. this study confirms the importance of intensive examinations for early detection of atherosclerosis and treatment of risk factors. patients and methods this cross-sectional study was included 205 patients with type 2 diabetes mellitus (t2dm). we recorded clinical and biochemical data su...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
acta medica iranicaجلد ۵۳، شماره ۷، صفحات ۴۲۵-۴۳۱
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023